Specificity of genome evolution in experimental populations of Escherichia coli evolved at different temperatures
Abstract
Organisms evolve and adapt via changes in their genomes that improve survival and reproduction in the context of their environment. Few experiments have examined how these genomic signatures of adaptation, which may favor mutations in certain genes or molecular pathways, vary across a set of similar environments that have both shared and distinctive characteristics. We sequenced complete genomes from 30 Escherichia coli lineages that evolved for 2,000 generations in one of five environments that differed only in the temperatures they experienced. Particular “signature” genes acquired mutations in these bacteria in response to selection imposed by specific temperature treatments. Thus, it is sometimes possible to predict aspects of the environment recently experienced by microbial populations from changes in their genome sequences.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 15, 2017
- Source ID
- 10.1073/pnas.1616132114
Entities
People
- Albert F. Bennett
- Daniel E. Deatherage
- Jamie L. Kepner
- Jeffrey E Barrick
- Richard E. Lenski
Organizations
- Cancer Prevention and Research Institute of Texas
- Michigan State University
- National Institutes of Health
- National Science Foundation
- University of California
- University of Texas at Austin