An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma
Abstract
The early detection of hepatocellular carcinoma (HCC) is of paramount importance for improving patient outcomes, yet an accurate, high-throughput screening methodology has yet to be developed. By combining microfluidic depletion of hematopoietic cells from blood specimens with absolute quantification of lineage-derived transcripts, we demonstrate the highly specific detection of circulating tumor cells, enabling noninvasive detection and clinical monitoring of HCC.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 17, 2017
- Source ID
- 10.1073/pnas.1617032114
Entities
People
- Alona Muzikansky
- Andrew X Zhu
- Daniel Haber
- David A Weitz
- David P. Ryan
- David T Ting
- David T. Miyamoto
- Hong Xin
- Huidan Zhang
- Irun Bhan
- John D. Milner
- Joseph A. Licausi
- Kurt Julius Isselbacher
- Lecia V. Sequist
- Lipika Goyal
- Mark Kalinich
- Mehmet Toner
- Melissa Choz
- Ravi Kapur
- Raymond T. Chung
- Sarah Javaid
- Shyamala Maheswaran
- Srinjoy Sil
- Tanya T. Kwan
- Uyen Ho
Organizations
- Foundation for the National Institutes of Health
- Harvard Medical School
- Harvard University
- Howard Hughes Medical Institute
- National Foundation for Cancer Research
- National Science Foundation
- Prostate Cancer Foundation
- United States Department of Defense