Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis
Abstract
The demonstration of a robust neurogenesis program in the adult gut and the existence of an enteric neural precursor cell (ENPC) responsible for the same has profound biological and clinical implications. This demonstrates the presence of robust adult neurogenesis outside of the CNS, and indicates the vulnerability of the enteric nervous system to exogenous influences, even in adults. As an example, it is possible that acquired diseases of the enteric nervous system, such as achalasia, may result from a loss of ENPC, analogous to congenital disorders, such as Hirschsprung’s. The ability to identify the adult ENPC will therefore enable a new understanding of the pathogenesis of enteric neuromuscular diseases as well as the development of novel regenerative therapies.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 18, 2017
- Source ID
- 10.1073/pnas.1619406114
Entities
People
- Changsik Shin
- Cuiping Li
- E. Michelle Southard-smith
- Grigori Enikolopov
- Hongjun Song
- Jenna Leser
- Laren Becker
- Li Qian
- Liansheng Liu
- Manish J. Butte
- Maria-adelaide Micci
- Michael Anderson
- Milena Bogunovic
- Monalee Saha
- Nikolai Rakhilin
- Pankaj J Pasricha
- Raj P. Kapur
- Shiue-cheng Tang
- Subhash Kulkarni
- Xiling Shen
- Xinzhong Dong
- Ya-yuan Fu
Organizations
- Cold Spring Harbor Laboratory
- Cornell University
- Duke University
- Howard Hughes Medical Institute
- Johns Hopkins School of Medicine
- Johns Hopkins University
- Kenneth Rainin Foundation
- March of Dimes
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institutes of Health
- National Tsing Hua University
- Pennsylvania State University
- Seattle Children's
- Stanford University
- Stony Brook University
- University of California, Los Angeles
- University of Texas Medical Branch
- Vanderbilt University