Human and rat gut microbiome composition is maintained following sleep restriction
Abstract
It is widely presumed that there is a relationship between sleep and the gut microbiome because both sleep restriction and dysbiosis of the gut microbiome are associated with metabolic diseases such as obesity and diabetes. Here, we report sleep restriction over several consecutive days does not overtly influence the composition of the microbiome of either rats or humans, despite both species showing other changes associated with sleep loss. These analyses suggest that sleep loss and microbial dysbiosis have independent effects on the development of metabolic diseases.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 08, 2017
- Source ID
- 10.1073/pnas.1620673114
Entities
People
- Amita Sehgal
- Aubrey Bailey
- Christopher J. Jang
- David F. Dinges
- Frederic D. Bushman
- Lei Bai
- Namni Goel
- Peter Meerlo
- Shirley L. Zhang
Organizations
- Children's Hospital of Philadelphia
- Howard Hughes Medical Institute
- National Aeronautics and Space Administration
- National Institute of Neurological Disorders and Stroke
- National Institute of Nursing Research
- Office of Naval Research
- University of Groningen
- University of Pennsylvania