Emergence of function from coordinated cells in a tissue
Abstract
A basic problem in biology is understanding how information from a single genome gives rise to function in a mature multicellular tissue. Genome dynamics stabilize to give rise to a protein distribution in a given cell type, which in turn gives rise to the identity of a cell. We build a highly idealized mathematical foundation that combines the genome (within cell) and the diffusion (between cell) dynamical forces. The trade-off between these forces gives rise to the emergence of function. We define emergence as the coordinated effect of individual components that establishes an objective not possible for an individual component. Our setting of emergence may further our understanding of normal tissue function and dysfunctional states such as cancer.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 30, 2017
- Source ID
- 10.1073/pnas.1621145114
Entities
People
- Indika Rajapakse
- Stephen Smale
Organizations
- University of Michigan