Specific detection of biomolecules in physiological solutions using graphene transistor biosensors
Abstract
Nanoelectronic transistor sensors based on synthesized one- and two-dimensional nanomaterials have achieved real-time label-free detection of a wide range of biological species with high sensitivity, although direct analysis of biological samples has been limited due to Debye charge screening in physiological solutions. This paper describes a general strategy overcoming this challenge involving comodification of the transistor sensor surface with a polymer and receptor, where the polymer forms a permeable layer that increases the effective screening length and receptor enables selective detection of analytes. The capability of this strategy was demonstrated with selective detection of cancer markers in physiological solution, thus opening substantial opportunities for real-time sensing applications in biology and medicine.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 05, 2016
- Source ID
- 10.1073/pnas.1625010114
Entities
People
- Anqi Zhang
- Charles M. Lieber
- Ning Gao
- Teng Gao
- Wei Zhou
- Xiaochuan Dai
- Yang Xiao
Organizations
- Air Force Office of Scientific Research
- Defense Threat Reduction Agency
- Harvard University