Stem cell-released oncolytic herpes simplex virus has therapeutic efficacy in brain metastatic melanomas
Abstract
This study provides an insight into stem cell-based oncolytic virus therapies for advanced melanoma tumors that have metastasized into the brain by developing clinically relevant mouse tumor models and testing the fate and efficacy of oncolytic herpes simplex virus-armed mesenchymal stem cells in such models. This study therefore overcomes the hurdles of systemic delivery of oncolytic viruses and provides a clinically applicable therapeutic platform to target melanoma brain metastasis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 14, 2017
- Source ID
- 10.1073/pnas.1700363114
Entities
People
- David Fisher
- Gihun Choi
- Hiroaki Wakimoto
- Ivan Seah
- Katrina Meeth
- Khalid Shah
- Marcus W. Bosenberg
- Oumaima Bougazzoul
- Wanlu Du
Organizations
- Congressionally Directed Medical Research Programs
- Harvard Medical School
- Harvard University
- National Cancer Institute
- Yale School of Medicine