Multigenerational silencing dynamics control cell aging
Abstract
Aging is an inevitable consequence of living, and with it comes increased morbidity and mortality. Novel approaches to mitigating age-related chronic diseases demand a better understanding of the biology of aging. Studies in model organisms have identified many conserved molecular factors that influence aging. The emerging challenge is to understand how these factors interact and change dynamically to drive aging. Using multidisciplinary technologies, we have revealed a sirtuin-dependent intermittent pattern of chromatin silencing during yeast aging that is crucial for longevity. Our findings highlight the important role of silencing dynamics in aging, which deserves careful consideration when designing schemes to delay or reverse aging by modulating sirtuins and silencing.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 03, 2017
- Source ID
- 10.1073/pnas.1703379114
Entities
People
- Jeff Hasty
- Lev S Tsimring
- Lorraine Pillus
- Meng Jin
- Nan Hao
- Philip Bittihn
- Richard O’laughlin
- Yang Li
Organizations
- Air Force Office of Scientific Research
- Division of Molecular & Cellular Biosciences
- University of California, San Diego