Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAAreceptors at inhibitory synapses
Abstract
Our knowledge of how estrogen signaling can influence inhibitory synaptic transmission is rudimentary and is addressed here. Collectively, our data suggest that estrogen modulates the dynamics of surface GABAAreceptors and hence efficacy of synaptic inhibition, via a postsynaptic mechanism that relies on disrupting the postsynaptic scaffold. This regulatory mechanism may have profound effects on the efficacy of neuronal inhibition and therefore synaptic plasticity and thus play a role in the pathophysiology of estrogen-related seizure and cognitive disorders.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 16, 2017
- Source ID
- 10.1073/pnas.1705075114
Entities
People
- Antoine Triller
- Deepak P. Srivastava
- Jamie Maguire
- Jayanta Mukherjee
- Menelas N. Pangalos
- Nicholas J. Brandon
- Ross A. Cardarelli
- Shiva K. Tyagarajan
- Stephen J. Moss
- Tarek Z. Deeb
- Yasmine Cantaut-belarif
Organizations
- AstraZeneca
- King's College London
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke
- PSL Research University
- Tufts University
- University College London
- University of Zurich