Theory of long binding events in single-molecule–controlled rotation experiments on F 1 -ATPase
Abstract
The treatment of nucleotide (ATP and ADP) binding and release in our previous papers is now extended to include a much wider range of rotor angles. It now treats composite events associated with ATP hydrolysis and ADP release and, in the reverse direction, ATP synthesis and release. A method of treating composite events is formulated and used to extract reaction rate constants in the system and to predict the lifetime distribution of long binding events that can be compared with and used to analyze future experimental data.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 26, 2017
- Source ID
- 10.1073/pnas.1705960114
Entities
People
- Rudolph A. Marcus
- Sándor Volkán-kacsó
Organizations
- Army Research Office
- California Institute of Technology
- Office of Naval Research Global