Production of diverse PET probes with limited resources: 24 18 F-labeled compounds prepared with a single radiosynthesizer
Abstract
Molecular imaging with PET can provide a dynamic, whole-body picture of the rate of biological processes or distribution of biological targets by tracking the distribution of radiolabeled molecules or particles in the body over time. Continual efforts to develop new PET probes are expanding the variety of processes and targets that can be visualized, facilitating basic research, drug development, and patient care. However, access to these probes at all stages of their development is hindered by high costs arising, in large part, from the significant resources that are typically dedicated to production of a single probe. Emerging technologies with increased synthesis flexibility are allowing increased probe diversity with fewer resources and could significantly increase access to new molecular imaging agents.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 10, 2017
- Source ID
- 10.1073/pnas.1710466114
Entities
People
- Bin Shen
- Christopher Drake
- Christopher M. Waldmann
- Frederick T. Chin
- Jeffrey Collins
- Jennifer M Murphy
- Mark Lazari
- Maxim Sergeev
- Melissa Moore
- Michael E. Phelps
- Noel S. Ha
- R Michael van Dam
- Roger Slavik
- Saman Sadeghi
Organizations
- National Cancer Institute
- National Institute of Biomedical Imaging and Bioengineering
- National Institute on Aging
- Stanford University
- United States Department of Defense
- United States Department of Energy
- United States Department of Health and Human Services
- University of California, Los Angeles