Insight from the maximal activation of the signal transduction excitable network in Dictyostelium discoideum
Abstract
Directed cell migration is at the center of the pathophysiology of many diseases such as cancer. It requires the coordination of a signal transduction network and an underlying cytoskeleton. Understanding the composition of these networks and the mechanism by which they are coupled is critical to furthering our understanding of how cells move. Here, we have developed a cell-based tool which maximizes the activation of the signal transduction system. This has provided us with insight into its composition and the mechanism by which it controls the activity of the actin cytoskeletal activity, which drives migration. Most striking, the persistent activation of the signal transduction apparatus was discovered to have severe consequences for cell viability.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 30, 2018
- Source ID
- 10.1073/pnas.1710480115
Entities
People
- Bedri Abubaker-sharif
- Huaqing Cai
- Marc Edwards
- Peter N. Devreotes
- Thomas J. Lampert
- Yu Long
Organizations
- Air Force Office of Scientific Research
- Chinese Academy of Sciences
- Johns Hopkins University
- National Institutes of Health