Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models
Abstract
We have experimentally investigated the immunoregulatory effects of human gut microbiota in multiple sclerosis (MS). We have identified specific bacteria that are associated with MS and demonstrated that these bacteria regulate T lymphocyte-mediated adaptive immune responses and contribute to the proinflammatory environment in vitro and in vivo. Thus, our results expand the knowledge of the microbial regulation of immunity and may provide a basis for the development of microbiome-based therapeutics in autoimmune diseases.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 11, 2017
- Source ID
- 10.1073/pnas.1711235114
Entities
People
- Bruce A C Cree
- Bryan B. Yoo
- Charlotte A. Nelson
- Egle Cekanaviciute
- Elizabeth Crabtree-hartman
- Ilana Katz Sand
- Justine W. Debelius
- Mar Gacias
- Patrizia Casaccia
- Rachel Kanner
- Rob Knight
- Sarkis Mazmanian
- Sergio E Baranzini
- Sneha Singh
- Stephen L. Hauser
- Tessel F. Runia
- Yadira Bencosme
- Yun Kyung Lee
- Yunjiao Zhu
Organizations
- California Institute of Technology
- City University of New York
- Icahn School of Medicine at Mount Sinai
- National Multiple Sclerosis Society
- United States Department of Defense
- University of California
- University of California, San Diego