Long-term dopamine neurochemical monitoring in primates
Abstract
Dopamine is an important neurotransmitter governing behavior and heavily implicated in a large range of neural disorders, including Parkinson’s disease, depression, and related mood and movement disorders. Methods allowing accurate monitoring of dopamine over long timescales have not been previously reported yet are crucial to enable improved diagnostics and therapeutics. We report a technical advance that allowed recording of dopamine from sensors implanted into the brains of nonhuman primates for over 100 days. Our integrated platform enabled monitoring fast changes in dopamine release in response to rewarding stimuli and the administration of dopamine-related drugs. These findings demonstrate the long-term feasibility and reproducibility of neurochemical measurements and strengthen their potential translation to human use.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 20, 2017
- Source ID
- 10.1073/pnas.1713756114
Entities
People
- Ann Graybiel
- Daniel J. Gibson
- Helen N Schwerdt
- Hideki Shimazu
- Ken-Ichi Amemori
- Michael J Cima
- Patrick L. Tierney
- Robert S. Langer, Jr.
- Satoko Amemori
- Simon Hong
- Tomoko Yoshida
Organizations
- Army Research Office
- Massachusetts Institute of Technology
- National Institute of Biomedical Imaging and Bioengineering
- National Institute of Neurological Disorders and Stroke