Origin of slow spontaneous resting-state neuronal fluctuations in brain networks
Abstract
Resting-state infra-slow brain activity fluctuations are observed across various cognitive and disease brain states. Although resting-state fluctuations have received a great deal of interest over the past few years, the underlying biophysical mechanisms are not known. Using computational modeling, we show that spontaneous resting-state fluctuations arise from dynamic ion concentrations and are influenced by the Na + /K + pump, glial K + buffering, and AMPA/GABA synaptic currents. These findings provide insights into the biophysical mechanisms underlying generation of this phenomenon and may lead to better understanding of how different cognitive or disease states influence resting-state activity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 08, 2018
- Source ID
- 10.1073/pnas.1715841115
Entities
People
- Giri P Krishnan
- Maxim Bazhenov
- Oscar C González
Organizations
- National Science Foundation
- Office of Naval Research
- University of California, San Diego