Lamellipodium is a myosin-independent mechanosensor
Abstract
Cell physiology can be regulated by the mechanics of the extracellular environment. Here, we demonstrate that cell spreading is a mechanosensitive process regulated by weak forces generated at the cell periphery and independent of motor activity. We show that stiffness sensing depends on the kinetics of the initial adhesion bonds that are subjected to forces driven by protein polymerization. This work demonstrates how the binding kinetics of adhesion molecules are sensitively tuned to a range of forces that enable mechanosensation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 27, 2018
- Source ID
- 10.1073/pnas.1715869115
Entities
People
- Austin V. Skeeters
- Gregory A. Voth
- Guillermina R. Ramirez-san Juan
- Margaret Gardel
- Patrick W Oakes
- Stephen P. Winter
- Tamara C. Bidone
- Yvonne Beckham
Organizations
- Army Research Office
- National Institute of General Medical Sciences
- University of Chicago
- University of Rochester