Carbon monoxide protects the kidney through the central circadian clock and CD39
Abstract
Tissue injury caused by lack of blood flow results in a series of adaptive responses of the body to ensure survival. Cellular production of carbon monoxide (CO) preserves organ function and promotes healing. How this occurs has remained elusive. Here we demonstrate using a model of ischemia reperfusion injury (IRI) of the kidney, mimicking kidney transplant, that safe administration of CO protects against IRI. Remarkably, this occurs through specific modulation of a gene that regulates energy metabolism (CD39) and one that controls circadian rhythm (Period 2). Collectively, we define here an innovative signaling pathway linking the brain and the kidney vis a vis a gas molecule. These data may have important therapeutic consequences for transplant recipients and victims of stroke.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 20, 2018
- Source ID
- 10.1073/pnas.1716747115
Entities
People
- Binghe Wang
- Carl J. Hauser
- David Gallo
- Edward Gomperts
- Eva Csizmadia
- Judith-lisa Lieberum
- Leo E Otterbein
- Matheus Correa-costa
- Niels Olsen Saraiva Câmara
- Simon C. Robson
- Xingyue Ji
Organizations
- Congressionally Directed Medical Research Programs
- Georgia State University
- Harvard Medical School
- National Institute of Allergy and Infectious Diseases
- University of São Paulo