Identification of cytokine-specific sensory neural signals by decoding murine vagus nerve activity
Abstract
Evolution conferred animals with molecular sensors that monitor cellular and organ function to detect changes in the environment. These activate sensory neural responses that drive the action of reflexes that maintain cellular and physiological homeostasis. Recent advances reveal that neural reflexes modulate the immune system, but it was previously unknown whether cytokine mediators of immunity mediate specific neural signals. Here we develop methods to isolate and decode specific neural signals recorded from the vagus nerve to discriminate between the cytokines IL-1β and TNF. This methodological waveform successfully detects and discriminates between specific cytokine exposures using neural signals.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 07, 2018
- Source ID
- 10.1073/pnas.1719083115
Entities
People
- Chad E. Bouton
- Emily Battinelli
- Harold A. Silverman
- Jeffrey M. Ashe
- Kevin J. Tracey
- Peter W. Lorraine
- Sangeeta S Chavan
- Theodoros P. Zanos
- Todd Levy
- Téa Tsaava
Organizations
- General Electric
- National Institute of General Medical Sciences