Robust, linear correlations between growth rates and β-lactam–mediated lysis rates
Abstract
How fast bacteria grow influences the efficacy of β-lactams, one of the most commonly used classes of antibiotics. However, the quantitative nature of this correlation is not well established. With precise measurements and analyses enabled by experimental automation, we found a robust relationship between growth and lysis rates that is generally applicable to diverse pairs of β-lactams and bacteria. That is, the growth rate of population serves as a reliable predictor for the lysis rate in response to a β-lactam. This quantitative correlation lays the foundation for predicting bacterial population dynamics during β-lactam treatments. This predictive capability is critical for designing effective antibiotic dosing protocols, in addressing the rising antibiotic resistance crisis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 02, 2018
- Source ID
- 10.1073/pnas.1719504115
Entities
People
- Anna J Lee
- Bihan Zhuang
- Hannah R. Meredith
- Lingchong You
- Shangying Wang
- Zhuojun Dai
Organizations
- Army Research Office
- David and Lucile Packard Foundation
- Duke University
- National Institutes of Health