Flight motor networks modulate primary olfactory processing in the moth Manduca sexta
Abstract
Across vertebrates and invertebrates, corollary discharge circuits (CDCs) project to and inform sensory networks about an animal’s movements, which directly impact sensory processing. Failure of CDCs likely underlie sensory hallucinations in schizophrenia, Parkinson’s disease, and dyspnea, highlighting the fundamental importance of CDCs for successfully interpreting sensory cues to adaptively interact with the external world. Ultimately, understanding the role of CDCs in integrating sensory motor function will be vital to understand these diseases, but mechanistically little is known about how CDCs function. CDCs have been identified in most sensory domains except olfaction. Our findings indicate that a histaminergic CDC enhances the ability of the olfactory system to more precisely encode stimulus temporal structure, resulting in enhanced olfactory acuity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 07, 2018
- Source ID
- 10.1073/pnas.1722379115
Entities
People
- Andrew M Dacks
- Benjamin Houot
- Kevin C. Daly
- Phillip D. Chapman
- Rex Burkland
- Samual P. Bradley
- Victoria Bullman
Organizations
- Air Force Office of Scientific Research
- National Institute on Deafness and Other Communication Disorders
- West Virginia University