Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism
Abstract
Shift workers, whose schedules are misaligned relative to their suprachiasmatic nuclei (SCN) circadian pacemaker, are at elevated risk of metabolic disorders. In a study of simulated day- versus night-shift work followed by a constant routine, we separated plasma-circulating metabolites according to whether their 24-h rhythms aligned with the central SCN pacemaker or instead reflected externally imposed behavioral schedules. We found that rhythms in many metabolites implicated in food metabolism dissociated from the SCN pacemaker rhythm, with the vast majority aligning with the preceding sleep/wake and feeding/fasting cycles. Our metabolomics study yields insight into the link between prolonged exposure to shift work and the spectrum of associated metabolic disorders by providing a window into peripheral oscillators and the biobehavioral factors that orchestrate them.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 10, 2018
- Source ID
- 10.1073/pnas.1801183115
Entities
People
- Benita Middleton
- Brieann C Satterfield
- Debra J. Skene
- Elena Skornyakov
- Hans P A Van Dongen
- Kenneth I Porter
- Namrata R. Chowdhury
- Rajendra P Gajula
- Shobhan Gaddameedhi
Organizations
- Biotechnology and Biological Sciences Research Council
- Congressionally Directed Medical Research Programs
- Eastern Washington University
- National Institute of Environmental Health Sciences
- University of Arizona
- University of Surrey
- Washington State University