Hippocampus-dependent emergence of spatial sequence coding in retrosplenial cortex
Abstract
Retrosplenial cortex (RSC) is a major relay of hippocampal formation output to other neocortical areas and is critical for spatial and some other forms of learning. We show here that the sparse, orthogonal, “place cell” sequence activity in RSC develops gradually over several days and is severely attenuated by hippocampal damage. These data support the theory that hippocampus endows RSC (and possibly other cortical areas) with an index-like, continuous representation of the context in which events occur, that could support coordinated retrieval of recent memory.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 16, 2018
- Source ID
- 10.1073/pnas.1803224115
Entities
People
- Adam R. Neumann
- Bruce L. McNaughton
- Dun Mao
- Jianjun Sun
- Majid H Mohajerani
- Vincent Bonin
Organizations
- Alberta Innovates – Health Solutions
- Canada Foundation for Innovation
- Flanders Institute for Biotechnology
- Katholieke Universiteit Leuven
- National Science Foundation
- Natural Sciences and Engineering Research Council
- Research Council, KU Leuven
- Research Foundation - Flanders
- University of California
- University of Lethbridge