Grid-like hexadirectional modulation of human entorhinal theta oscillations
Abstract
The entorhinal cortex plays a critical role in allowing organisms to navigate and represent spatial memories using grid-like representations. Given the importance of spatial processing for everyday life, we examined the patterns of neuronal oscillations in the entorhinal cortex, which are thought to underlie grid cells, in humans using intracranial recordings from neurosurgical patients as they navigated in virtual reality. We show that the power of entorhinal theta oscillations shows a distinctive six-way symmetric directional modulation, suggesting they correlate with grid representations, and that this signal correlates with spatial memory performance. Our findings thus show that the human entorhinal grid network is associated with theta oscillations and indicate that it is possible to measure properties of grid-like neural representations by recording oscillations.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 03, 2018
- Source ID
- 10.1073/pnas.1805007115
Entities
People
- Joel M Stein
- Jonathan Miller
- Joshua Jacobs
- Shachar Maidenbaum
Organizations
- Columbia University
- National Institute of Mental Health
- University of Pennsylvania