Biased competition in the absence of input bias revealed through corticostriatal computation
Abstract
The canonical model of the basal ganglia is based on competing direct (GO) vs. indirect (NO-GO) pathways. However, how is either of the two pathways activated if they receive the same corticostriatal inputs as experimental evidence suggests? Also, in the context of rule-based decisions, how is a specific action selected among competing GO pathways? We introduce a neural circuit model that identifies three alternative mechanisms flexibly supporting preferential processing between GO and NO-GO alternatives under balanced input. Only one of these mechanisms, however, is capable of enabling action selection by reinforcing, in the striatum, the rule-based rhythmic biases reported in prefrontal cortex.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 08, 2019
- Source ID
- 10.1073/pnas.1812535116
Entities
People
- Benjamin R. Pittman-polletta
- Jason S. Sherfey
- Joachim Hass
- Michelle M. Mccarthy
- Nancy Kopell
- Salva Ardid
Organizations
- Army Research Office
- Boston University
- Heidelberg University
- National Institutes of Health
- National Science Foundation