Litters of self-replicating origami cross-tiles
Abstract
In nature, self-replication and exponential growth are common. Here we introduce a system of artificial self-replicators based on DNA origami cross-tile motifs. Unlike previous systems based on making a single copy of a parent template, the cross-tile systems, like many natural species, can produce “litters” of offspring per generation. The cross-tiles enable a ladder-like structure to crystallize from the template on cooling. UV exposure covalently binds the assembled components of the offspring and heating releases the autonomous daughters from the parent, up to 10 offspring per cycle. The enhanced growth rate speeds up experimental studies and provides an evolutionary advantage for selection.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 23, 2019
- Source ID
- 10.1073/pnas.1812793116
Entities
People
- Feng Zhou
- Nadrian C. Seeman
- Paul Chaikin
- Rebecca Zhuo
- Ruojie Sha
- Xiaojin He
Organizations
- Army Research Office
- National Science Foundation
- New York University
- Office of Naval Research
- United States Department of Energy