Conductively coupled flexible silicon electronic systems for chronic neural electrophysiology
Abstract
A critical challenge for flexible biomedical implants is in the development of materials and structures that enable intimate coupling to biotissues with long-term stability. The results presented here address this problem through a materials and integration strategy that combines highly doped silicon nanomembranes chemically bonded to thin films of thermal silicon dioxide in a construct that simultaneously serves as a biofluid barrier and a conductively coupled biointerface. Use of this approach with various flexible electronic systems, including passive and active electrodes for electrophysiological sensing and electrical stimulation, illustrate capabilities in high-fidelity operation. Systematic accelerated lifetime studies in artificial biofluids highlight the stability of these systems for chronic operation, without electrical leakage or other forms of degradation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 18, 2018
- Source ID
- 10.1073/pnas.1813187115
Entities
People
- Charles Wang
- Chia-Han Chiang
- Enming Song
- Guanhua Fang
- Haina Du
- Jahyun Koo
- Jinghua Li
- Jize Zhang
- John A. Rogers
- Jonathan Viventi
- Ki Jun Yu
- Limei Tian
- Mackenna Hill
- Yiding Zhong
- Yishan Zhong
- Yisong Chen
Organizations
- Duke University
- National Research Foundation of Korea
- Northwestern University
- University of Illinois Urbana–Champaign
- Yonsei University