Transcranial alternating current stimulation entrains single-neuron activity in the primate brain
Abstract
Neurostimulation is a common therapy for a variety of neurological disorders, but the most effective stimulation approaches are often highly invasive, requiring electrodes to be implanted deep within brain structures like the hippocampus and basal ganglia. Here, we show that transcranial electrical stimulation (tES), a neuromodulatory technique that uses electrodes placed outside the scalp, can also affect patterns of neural activity in these areas. We find that tES can reliably control the timing, but not the rate, of spikes in individual neurons. Because changes in spike timing are thought to play a key role in many brain functions, the data shown here suggest that tES may be a valuable tool for clinical and fundamental studies of the human brain.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 04, 2019
- Source ID
- 10.1073/pnas.1815958116
Entities
People
- Bennett A. Csorba
- Christopher C. Pack
- Matthew R. Krause
- Pedro G Vieira
- Praveen K Pilly
Organizations
- HRL Laboratories
- Institute of Neurosciences, Mental Health and Addiction
- McGill University