Evolution of resilience in protein interactomes across the tree of life
Abstract
The interactome network of protein–protein interactions captures the structure of molecular machinery that underlies organismal complexity. The resilience to network failures is a critical property of the interactome as the breakdown of interactions may lead to cell death or disease. By studying interactomes from 1,840 species across the tree of life, we find that evolution leads to more resilient interactomes, providing evidence for a longstanding hypothesis that interactomes evolve favoring robustness against network failures. We find that a highly resilient interactome has a beneficial impact on the organism’s survival in complex, variable, and competitive habitats. Our findings reveal how interactomes change through evolution and how these changes affect their response to environmental unpredictability.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 14, 2019
- Source ID
- 10.1073/pnas.1818013116
Entities
People
- Jure Leskovec
- Marcus W. Feldman
- Marinka Žitnik
- Rok Sosič
Organizations
- Boeing
- Center for Computational, Evolutionary and Human Genomics, Stanford University
- Chan Zuckerberg Biohub
- Chan Zuckerberg Initiative
- John Templeton Foundation
- National Institutes of Health
- National Science Foundation
- Stanford University