Cofilin drives rapid turnover and fluidization of entangled F-actin
Abstract
When an animal cell moves or divides, a disordered network of actin filaments (F-actin) builds mechanical scaffolds to drive cell-shape changes. Actin filaments are undergoing continual cycles of assembly and disassembly, known as turnover, but it is unknown how these dynamics impact the mechanical properties of actin-filament-based networks. Here, we show that actin-filament turnover dynamics contribute to mechanical stress relaxation. Additionally, we identify the factors necessary to generate a nonequilibrium steady state of dynamic actin filaments that provides a picture of their regulation in vivo.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 12, 2019
- Source ID
- 10.1073/pnas.1818808116
Entities
People
- David R. Kovar
- Frederick C. Mackintosh
- Margaret Gardel
- Patrick M McCall
Organizations
- Army Research Office
- National Science Foundation
- Rice University
- University of Chicago