Early detonation by sprouted mossy fibers enables aberrant dentate network activity
Abstract
Sprouted mossy fibers are one of the hallmark histopathological findings in experimental and human temporal lobe epilepsy. These fibers form recurrent excitatory synapses onto other dentate granule cells that display profound short-term depression. Here, however, we show that although these sprouted mossy fibers weaken substantially during repetitive activation, their initial high probability of glutamate release can activate reverberant network activity. Furthermore, we find that a lack of tonic adenosine inhibition enables this high probability of release and, consequently, recurrent network activity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 13, 2019
- Source ID
- 10.1073/pnas.1821227116
Entities
People
- Eric Schnell
- Gary L Westbrook
- William D Hendricks
Organizations
- Congressionally Directed Medical Research Programs
- National Institute of Neurological Disorders and Stroke
- United States Department of Veterans Affairs