X-ray induced photodynamic therapy with copper-cysteamine nanoparticles in mice tumors
Abstract
Copper-cysteamine nanoparticles can be activated directly by X-rays to produce singlet oxygen. The use of copper-cysteamine nanoparticles (conjugated with pH-low insertion peptide) can enhance the effects of X-ray–induced photodynamic therapy, to lead to improved tumor treatment in mice. The results of this study demonstrate the potential of copper-cysteamine nanoparticles with deeply penetrating X-rays in the treatment of mammalian cancer to overcome current limitations of low penetration, light-induced photodynamic therapy treatment that can only treat superficial cancers.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 01, 2019
- Source ID
- 10.1073/pnas.1900502116
Entities
People
- Adam Vanasse
- Bindeshwar Sah
- Gen Li
- Huibin Zheng
- Jing Wu
- Leon Cooper
- Lun Ma
- Michael P. Antosh
- Samana Shrestha
- Wei Chen
Organizations
- Brown University
- National Cancer Institute
- National Institute of General Medical Sciences
- United States Army
- University of Rhode Island
- University of Texas at Austin