β-Catenin is required for radial cell patterning and identity in the developing mouse cochlea
Abstract
The cochlea is essential for sound detection. It consists of highly differentiated hair cells and nonsensory supporting cells radially patterned into lateral and medial compartments. However, mechanisms regulating radial patterning and specification of hair cell and supporting cell subtypes, each of which serves unique functions, are unclear. Here we show that β-catenin is required for radial patterning and differentiation of sensory and nonsensory cell subtypes in the developing cochlea. β-Catenin-deleted cochleae displayed disrupted compartment borders containing ectopic hair cell and supporting cell subtypes, whereas inhibiting transcriptional and preserving cell adhesion-mediated activities of β-catenin maintained radial patterning and cell identity. This study thus characterizes a role for β-catenin-mediated cell adhesion in the developing cochlea.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 30, 2019
- Source ID
- 10.1073/pnas.1910223116
Entities
People
- Alan G Cheng
- David M. Ornitz
- Jessica W Shen
- Lee A. Quiruz
- Lina Jansson
- Michael Ebeid
- Sung-Ho Huh
- Tara E. Mokhtari
Organizations
- Formas
- National Institute of General Medical Sciences
- National Institute on Deafness and Other Communication Disorders
- Nebraska Department of Health and Human Services
- Stanford University
- United States Department of Defense
- University of Nebraska–Lincoln
- Washington University in St. Louis