Treg-inducing microparticles promote donor-specific tolerance in experimental vascularized composite allotransplantation
Abstract
Vascularized composite allotransplantation (VCA) is an emerging field that is particularly beneficial for select amputees and patients with devastating soft tissue loss that is not amenable to conventional reconstructive surgeries. As with solid organ transplantation, VCA recipients are subjected to a lifelong regimen of antirejection drugs with a well-established sequela. Herein, we report a synthetic, controlled-release microparticle system (referred to as TRI-MP) that aims to locally enrich naturally occurring, suppressive lymphocytes to prevent allograft rejection and promote tolerance. While this study exclusively focuses on VCA, this technology has implications for other conditions characterized by aberrant inflammation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 02, 2019
- Source ID
- 10.1073/pnas.1910701116
Entities
People
- Abhinav P. Acharya
- Ali Mubin Aral
- Angus W. Thomson
- Chiaki Komatsu
- Heth Turnquist
- James D Fisher
- Jignesh V. Unadkat
- Jonas T. Schnider
- Liwei Dong
- Mario G. Solari
- Riccardo Schweizer
- Stephen C Balmert
- Steven R. Little
- Vasil E. Erbas
- Vijay S Gorantla
- Wensheng Zhang
- Yalçın Külahçı
Organizations
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Dental and Craniofacial Research
- United States Department of Defense
- University of Pittsburgh
- Wake Forest School of Medicine