Differential requirements for FcγR engagement by protective antibodies against Ebola virus
Abstract
In recent years, systematic research efforts have led to the preclinical development of antibody-based therapeutics that confer potent antiviral activity against Ebola virus (EBOV). Immunoglobulin G (IgG) antibodies against virus pathogens depend on their interaction with specialized leukocyte receptors (Fcγ receptors [FcγRs]) to confer antiviral functions. FcγR engagement by IgG antibodies induces leukocyte activation and mediates pleiotropic effector functions to control virus infection. Here, we examined the contribution of FcγR engagement to the antibody-mediated protection against EBOV infection in unique animal models of EBOV infection. Our findings suggest that anti-EBOV antibodies exhibit differential requirements for FcγR engagement to confer protection from EBOV infection, guiding the design of optimized antibody-based therapeutics with maximal protective efficacy.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 04, 2019
- Source ID
- 10.1073/pnas.1911842116
Entities
People
- Arthur J Goff
- David J. Dilillo
- Jeffrey Ravetch
- Pamela J Glass
- Stylianos Bournazos
Organizations
- The Rockefeller University
- United States Army Medical Research Institute of Infectious Diseases