Chronicling changes in the somatosensory neurons after peripheral nerve injury
Abstract
In this work, cell-specific temporal changes that occur in DRG neurons after peripheral nerve injury were monitored. Altered responses of neurons to bradykinin, ATP, and acetylcholine were observed; three bradykinin responsive neuronal cell types appear that correlate with increased pain. The ability to temporally monitor cell-specific alterations in receptors and ion channels (termed as “Pigafetta Disease Chronicles”) should make it possible to uncover cell type-specific disease-relevant alterations in membrane macromolecules and potentially identify drug targets whose function is required to establish a pathological state. This opens up the possibility of designing novel therapeutic interventions that do not merely treat disease symptoms but prevent a pathological state altogether.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 05, 2020
- Source ID
- 10.1073/pnas.1922618117
Entities
People
- Baldomero Olivera
- Frank Porreca
- Jennifer Y. Xie
- Jortan O Tun
- Kevin Chase
- Lu Dong
- Mario J. Giacobassi
- Russell W. Teichert
- Shrinivasan Raghuraman
Organizations
- National Institute of General Medical Sciences
- New York Institute of Technology
- United States Department of Defense
- University of Utah