Gene coexpression patterns predict opiate-induced brain-state transitions
Abstract
Persistent alterations to neural circuitry may help to explain why opiate abuse liability is higher among individuals with a history of chronic exposure. In this study, we employ a unique combination of computational approaches to understand how opiate-induced reorganization of network connectivity is supported by transcriptional and structural features of the brain. We identify a persistent reduction in FOS correlation network strength following opiate dependence and determine that correlated gene expression is predictive of opiate-induced changes in network connectivity. Further, we identify brain regions that influence the transition between opiate-naïve and opiate-dependent states. These findings establish a link between gene expression and changes in brain connectivity in response to opioids.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 21, 2020
- Source ID
- 10.1073/pnas.2003601117
Entities
People
- Carmen Weidler
- Danielle Bassett
- Eli J Cornblath
- Fabio Pasqualetti
- Julia K Brynildsen
- Julie Blendy
- Kyla D. Mace
Organizations
- Army Research Office
- National Institute on Drug Abuse
- National Science Foundation
- RWTH Aachen University
- University of California
- University of Pennsylvania