Genome-wide surveillance of transcription errors in response to genotoxic stress
Abstract
Accurate transcription is required for the faithful expression of genetic information. If the fidelity of transcription is compromised, protein homeostasis, cell fate, and various metabolic processes are disrupted. Here, we demonstrate that mutagens can lower the fidelity of transcription in yeast, worms, flies, and mice by promoting the misincorporation of nucleotides by RNA polymerases. These observations establish a mechanism by which the environment, our lifestyle choices, and work-related exposures may promote the age of onset, severity, and progression of various diseases.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 28, 2020
- Source ID
- 10.1073/pnas.2004077118
Entities
People
- Bérénice Benayoun
- Chi-Jui Chung
- Clark Fritsch
- Douglas C Wallace
- E. Mcgann
- J. Lagosh
- Jean-Francois Gout
- Kelley Thomas
- M. Lynch
- M. Vermulst
- Mohammad Aatif Bin Towheed
- P. S. Danthi
- S. Simpson
- Suraiya Haroon
- Xinmin Zhang
- Yiwen Song
Organizations
- American Federation for Aging Research
- Arizona State University
- Army Research Office
- Children's Hospital of Philadelphia
- Foundation for the National Institutes of Health
- Mississippi State University
- National Institute of Environmental Health Sciences
- Touro College of Osteopathic Medicine
- University of New Hampshire
- University of Pennsylvania
- University of Southern California