A folding reaction at the C-terminal domain drives temperature sensing in TRPM8 channels
Abstract
Sensory and homeostatic responses in several organisms depend on the exquisite temperature dependence of ion channels of the transient receptor potential family (thermo-TRP). To date, this temperature dependence has been explained either in terms of the existence of a dedicated temperature sensor or by the increase in the molar heat capacity during channel gating. We found that the Carboxy Terminus Domain (CTD) is required for temperature-driven gating of the cold-activated TRPM8 channel and that this domain folds in response to cold. Here we propose that the CTD of the TRPM8 channel is a bona fide temperature sensor that drives channel gating due to an increase in the molar heat capacity during the folded-to-unfolded transition.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 03, 2020
- Source ID
- 10.1073/pnas.2004303117
Entities
People
- Fernando Danilo González Nilo
- Ignacio Diaz-franulic
- Karen Castillo
- Natalia Raddatz
- Ramon Latorre
Organizations
- Air Force Office of Scientific Research
- Andrés Bello University
- CONICYT
- National Fund for Scientific and Technological Development
- University of Valparaíso