Tumor cell lysate-loaded immunostimulatory spherical nucleic acids as therapeutics for triple-negative breast cancer
Abstract
In mouse models of triple-negative breast cancer, we show that the oxidation of tumor cells prior to lysate generation, coupled with their compartmentalization in the core of liposomal spherical nucleic acids (SNAs) comprised of adjuvant DNA, yields a powerful immunotherapeutic that significantly inhibits tumor growth, dramatically extends survival, and promotes a tumoricidal immune cell population within the tumor microenvironment. Specifically, this work points toward the importance of properly packaging and presenting the adjuvant and antigens such that biodistribution, dendritic cell activation, and therapeutic efficacy can be controlled.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 15, 2020
- Source ID
- 10.1073/pnas.2005794117
Entities
People
- Caroline D Kusmierz
- Cassandra E Callmann
- Chad Mirkin
- Dai Horiuchi
- Lisa E. Cole
- Ziyin N. Huang
Organizations
- National Cancer Institute
- Northwestern University
- Office of Naval Research
- Prostate Cancer Foundation