Extracellular matrix plasticity as a driver of cell spreading
Abstract
In many biomaterial systems, plastic deformation of extracellular matrix, degradation, or relaxation of stress are coupled and therefore their effects on cell phenotype are difficult to isolate. Using a polymer plasticizing architecture that specifically decouples irreversible creep from stress relaxation and modulus, network plasticity is shown to have a biphasic relationship with cell spreading.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 05, 2020
- Source ID
- 10.1073/pnas.2008801117
Entities
People
- D.J. Mooney
- Joshua M Grolman
- Philipp Weinand
Organizations
- Harvard University
- National Institutes of Health
- United States Army