Coupling between slow waves and sharp-wave ripples engages distributed neural activity during sleep in humans
Abstract
Hippocampal sharp wave/ripples (SWRs) are implicated in binding distributed subcortical/cortical neuronal populations during sleep, supporting hippocampal-dependent memory consolidation. We assessed the activation and functional interactions between distributed populations during SWRs using intracranial electrophysiological recordings from human epileptic patients. Consistent phase relation between the hippocampal SWRs and local subcortical/cortical slow-wave activity (SWA) or spindles was a strong predictor of local neuronal activation during SWRs. In addition, individual SWR amplitude and SWA phase difference between the cortical sites during SWRs predicted the functional coupling between the distant cortical populations. Our findings suggest the SWR–SWA coupling as a mechanism for selecting and organizing the distributed populations for participation in global memory consolidation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 17, 2021
- Source ID
- 10.1073/pnas.2012075118
Entities
People
- Bruce L. McNaughton
- Bryce A. Mander
- Haoxin Zhang
- Ivan Skelin
- Jack J Lin
- Jie Zheng
- Olivia Kim McManus
- Robert T. Knight
- Shiting Ma
- Sumeet Vadera
Organizations
- Helen Wills Neuroscience Institute
- National Institute of Neurological Disorders and Stroke
- National Institutes of Health
- National Science Foundation
- Rady Children's Hospital
- University of California
- University of Lethbridge