Prdm16 is a critical regulator of adult long-term hematopoietic stem cell quiescence
Abstract
Regulation of quiescence is critical for the maintenance of adult HSCs, and the underlying mechanisms are poorly understood. Using a novel mouse conditional knockout allele of transcription factor gene Prdm16 , we show that its deletion in the adult hematopoietic system led to a gradual loss of adult HSCs over time. This loss of adult HSCs was associated with their significantly increased cycling. We further found that Prdm16 promotes the quiescence of adult HSCs by activating the transcription of HSC cell cycle inhibitors including Cdkn1a and Egr1 . Our study identifies Prdm16 as a critical regulator of adult HSC quiescence.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 02, 2020
- Source ID
- 10.1073/pnas.2017626117
Entities
People
- Bjorg Gudmundsdottir
- Kevin Oakley
- Kristbjorn O Gudmundsson
- Lino Tessarollo
- Nancy A. Jenkins
- Neal G. Copeland
- Nhu Nguyen
- Pentao Liu
- Yang Du
- Yufen Han
Organizations
- National Cancer Institute
- National Heart, Lung, and Blood Institute
- Uniformed Services University of the Health Sciences
- University of Hong Kong
- University of Texas at Austin