Early systemic immune biomarkers predict bone regeneration after trauma
Abstract
Chronic nonunion following traumatic bone injury remains a challenging clinical problem, and delayed treatment of an established nonunion is associated with variable outcomes and often prolonged patient disability. Here we used a rodent model of nonunion with delayed treatment to investigate the factors that influence effective healing. We found that certain immune profiles are linked to impaired bone regeneration. In particular, increased early levels of myeloid-derived suppressor cells and the cytokine interleukin-10 in blood are predictive of subsequent poor healing outcomes. These results suggest that the early systemic immune response to trauma can help predict the long-term effectiveness of bone healing treatments and may inform the development of immunotherapies for orthopedic repair.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 17, 2021
- Source ID
- 10.1073/pnas.2017889118
Entities
People
- Albert Cheng
- Casey E. Vantucci
- Krishnendu Roy
- L B Wood
- Laxminarayanan Krishnan
- M A Ruehle
- Robert E Guldberg
- Theresa Kotanchek
Organizations
- Armed Forces Institute of Regenerative Medicine
- Georgia Tech
- University of Oregon