Background-free dual-mode optical and13C magnetic resonance imaging in diamond particles
Abstract
We report on progress toward combining magnetic resonance imaging (MRI) and optical imaging in diamond microparticles. Our approach relies on the nitrogen vacancy (NV) center-driven optical nuclear hyperpolarizability in diamond particles, that renders them “bright” in MRI while simultaneously fluorescing optically. Both imaging modes allow suppression of background signals. We elucidate how such “dual-mode” imaging can perform better than either modes taken separately, leveraging relative strengths of optics and MRI with respect to resolution and imaging in scattering media. Finally, we propose a protocol for accelerated imaging that exploits the Fourier conjugacy in images obtained via optics and MRI. Our work suggests methods to combine optical and RF imaging in classes of deployable nanoparticles.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 17, 2021
- Source ID
- 10.1073/pnas.2023579118
Entities
People
- Alessandra Aguilar
- Alexander Pines
- Ashok Ajoy
- Carlos Meriles
- Daniel B. Vigneron
- Emanuel Druga
- Fanglin Linda Liu
- Fei Wang
- Jeffrey Reimer
- Jeffrey Walton
- Lan Wu
- Olga Shenderova
- Raffi Nazaryan
- Tommy Mcknelly
- Xudong Lv
Organizations
- City University of New York
- National Cancer Institute
- National Institutes of Health
- National Science Foundation
- Office of Naval Research
- Research Corporation
- University of California
- Yusuf Hamied Department of Chemistry