Compliant 3D frameworks instrumented with strain sensors for characterization of millimeter-scale engineered muscle tissues
Abstract
Tissue-on-chip systems offer important capabilities in engineering of living tissues for diverse biomedical applications in disease model studies, drug screening, and regenerative medicine. Conventional approaches use two-dimensional layouts that cannot suppport interfaces to geometrically complex three-dimensional (3D) tissue constructs in a deterministic fashion. Here, we present concepts in engineering systems that allow intimate contact with and stable mechanical coupling to 3D tissues for high-precision measurements of tissue contractility, as demonstrated in 3D, millimeter-scale engineered skeletal muscle tissues. These compliant, 3D frameworks instrumented with advanced sensors and other functional electronics, may significantly enhance the capabilities of tissue-on-chip systems.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 03, 2021
- Source ID
- 10.1073/pnas.2100077118
Entities
People
- Chenkai Xu
- Gelson J. Pagan-diaz
- Haibo Li
- Hangbo Zhao
- Heling Wang
- Jiaojiao Wang
- John A. Rogers
- Judy Suh
- M. Taher A. Saif
- Mengdi Han
- Onur Aydin
- Rashid Bashir
- Wei Lu
- Wubin Bai
- Xin Ning
- Yao Yao
- Yishan He
- Yongdeok Kim
- Yonggang Huang
- Yoonseok Park
Organizations
- Carle-Illinois College of Medicine
- Defense Threat Reduction Agency
- Division of Civil, Mechanical & Manufacturing Innovation
- National Institutes of Health
- National Science Foundation
- Northwestern University
- Office of Emerging Frontiers and Multidisciplinary Activities
- Peking University
- University of Illinois Urbana–Champaign
- University of Southern California