Preferential and persistent impact of acute HIV-1 infection on CD4+iNKT cells in colonic mucosa
Abstract
Evidence suggests that HIV-1 disease progression is determined in the early stages of infection. Here, preinfection invariant natural killer T (iNKT) cell levels were predictive of the peak viral load during acute HIV-1 infection (AHI). Furthermore, iNKT cells were preferentially lost in AHI. This was particularly striking in the colonic mucosa, where iNKT cells were depleted more profoundly than conventional CD4+T cells. The initiation of antiretroviral therapy during AHI-prevented iNKT cell dysregulation in peripheral blood but not in the colonic mucosa. Overall, our results support a model in which iNKT cells are early and preferential targets for HIV-1 infection during AHI.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 09, 2021
- Source ID
- 10.1073/pnas.2104721118
Entities
People
- Alexandra Schuetz
- Aljawharah Alrubayyi
- Amélie Pagliuzza
- Andrey Tokarev
- Bonnie M. Slike
- Chayada Sajjaweerawan
- Diane L Bolton
- Dominic Paquin Proulx
- Eugène Kroon
- Jintanat Ananworanich
- Johan K Sandberg
- Kerri G Lal
- Leigh Anne Eller
- Mark S. De Souza
- Matthew Creegan
- Merlin L Robb
- Michael A Eller
- Nelson Michael
- Nicolas Chomont
- Nitiya Chomchey
- Nittaya Phanuphak
- Rungsun Rerknimitr
- Rv217
- Rv254/search010
- Rv304/search013
- Shelly J. Krebs
- Study Groups
- Suchada Suhkumvittaya
- Suteeraporn Pinyakorn
- Yuwadee Phuang-ngern
Organizations
- Armed Forces Research Institute of Medical Sciences
- Chulalongkorn University
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- Karolinska Institutet
- National Institute of Allergy and Infectious Diseases
- National Institute of Infectious Diseases
- United States Department of Defense
- University of Amsterdam
- Université de Montréal
- Walter Reed Army Institute of Research