Pregnancy and weaning regulate human maternal liver size and function
Abstract
These human data are consistent with reproductive control of liver size and function in women and concur with recent observations in rodents, suggesting a conserved liver biology. The question of whether this described liver biology has implications for maternal health during pregnancy or sex-specific risk for liver disease remains to be determined. However, our evidence suggestive of weaning-induced liver involution in women may lead to improved understanding of the high rates of liver metastasis observed in young postpartum breast cancer patients.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 22, 2021
- Source ID
- 10.1073/pnas.2107269118
Entities
People
- Alexander R. Guimaraes
- Alexandra Bartlett
- Andrea E. DeBarber
- Eric Baetscher
- Erica T Goddard
- Jonathan Q Purnell
- Kimberly K. Vesco
- Melanie Francisco
- Michael C. Leo
- Patrick Catalano
- Pepper J Schedin
- William D. Rooney
- Willscott Naugler
- Xiangnan Guan
- Zheng Xia
Organizations
- Fred Hutchinson Cancer Center
- National Institute of Diabetes and Digestive and Kidney Diseases
- Tufts University
- United States Department of Defense
- University of Colorado