The E3 ubiquitin ligase adaptor Tango10 links the core circadian clock to neuropeptide and behavioral rhythms
Abstract
In animals, the control of daily sleep–wake rhythms is mediated by discrete circadian clock neurons via their rhythmic activity–dependent release of neuropeptides and neurotransmitters. Here, we describe a gene, Tango10 , critical for daily behavioral rhythms. TANGO10 functions as an adaptor with its partner, the E3 ubiquitin ligase CULLIN 3, to regulate protein ubiquitination, neuronal excitability via voltage-gated potassium channels, and neuropeptide accumulation. These studies define a mechanism for control of neuronal excitability and daily rhythmicity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 19, 2021
- Source ID
- 10.1073/pnas.2110767118
Entities
People
- Bridget C. Lear
- Casey O Diekman
- Chunghun Lim
- Eric G. Johnson
- Jack Curran
- Jongbin Lee
- Matthew Moye
- Ravi Allada
- Tae Hee Han
- Tomas Andreani
- William L. Kath
Organizations
- KAIST
- National Institute of Neurological Disorders and Stroke
- National Research Foundation of Korea
- National Science Foundation Division of Mathematical Sciences
- New Jersey Institute of Technology
- Northwestern University
- Ulsan National Institute of Science and Technology
- United States Department of Defense