Synchronous spiking of cerebellar Purkinje cells during control of movements
Abstract
The information that one region of the brain transmits to another is usually viewed through the lens of firing rates. However, if the output neurons could vary the timing of their spikes, then, through synchronization, they would spotlight information that may be critical for control of behavior. Here we report that, in the cerebellum, Purkinje cell populations that share a preference for error convey, to the nucleus, when to decelerate the movement, by reducing their firing rates and temporally synchronizing the remaining spikes.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 29, 2022
- Source ID
- 10.1073/pnas.2118954119
Entities
People
- Ehsan Sedaghat-Nejad
- Jay S. Pi
- Mohammad Amin Fakharian
- Paul Hage
- Reza Shadmehr
Organizations
- Institute for Research in Fundamental Sciences
- Johns Hopkins School of Medicine
- National Eye Institute
- National Institute of Neurological Disorders and Stroke
- National Science Foundation Directorate for Biological Sciences
- Office of Naval Research Global