Members of the KCTD family are major regulators of cAMP signaling
Abstract
Neuromodulation is pivotal for brain function. One of the key pathways engaged by neuromodulators is signaling via second messenger cAMP, which controls a myriad of fundamental reactions. This study identifies KCTD5, a ubiquitin ligase adapter, as a regulatory element in this pathway and determines that it works by an unusual dual mode controlling the activity of cAMP-generating enzyme in neurons through both zinc transport and G protein signaling.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 21, 2021
- Source ID
- 10.1073/pnas.2119237119
Entities
People
- Brian D. Young
- Brian S. Muntean
- Douglas C. Sloan
- James A. Wohlschlegel
- Kirill A. Martemyanov
- Subhi Marwari
- Xiaona Li
Organizations
- Medical College of Georgia
- National Institute on Drug Abuse
- Scripps Research
- United States Department of Defense
- University of California, Los Angeles